Hand eczema and other inflammatory skin diseases: efficacy of oral alitretinoin
نویسندگان
چکیده
Background Alitretinoin is a vitamin A derivative. It’s a pan-agonist of Retinoic Acid Receptors and Retinoid X Receptors. It interferes with keratinocytes’ proliferation and differentiation and exerts immunomodulatory and anti-inflammatory activity. Its clinical efficacy in the treatment of chronic hand eczema is well demonstrated. Recently, various case reports and case series pointed out its efficacy in other skin inflammatory disorders such as atopic dermatitis, psoriasis, lichen planus, Darier’s disease, Hailey Hailey’s disease, lichen simplex, pityriasis rubra pilaris and cutaneous lupus erythematosus.
منابع مشابه
Alitretinoin for the treatment of chronic hand eczema: clinical rationale
2014 Chronic hand eczema (CHE), an inflammatory skin disease, places heavy psychosocial and economic burden on the affected individual and society as a whole. Patch testing is recommended to identify potential causative allergens in each patient. Efficacy of traditional topical treatments render the management of CHE challenging. Oral alitretinoin (9-cis-retinoic acid) is a new drug for the tre...
متن کاملUpdate on the use of alitretinoin in treating chronic hand eczema
Chronic hand eczema is a debilitating dermatological condition with significant economic, social, and functional impacts. To date, conventional treatments such as topical corticosteroids, phototherapy, and systemic immunosuppressants have yielded disappointing results, owing to either a lack of efficacy or significant adverse events. Oral alitretinoin (9-cis-retinoic acid) is a unique panagonis...
متن کاملEfficacy and Safety of Alitretinoin for Chronic Hand Eczema in Korean Patients
BACKGROUND Chronic hand eczema (CHE) tends to be refractory to conventional therapy. Previous clinical trials have found that a 24-week treatment course of oral alitretinoin is effective and well tolerated for CHE treatment. OBJECTIVE The aim of this study was to investigate the efficacy and safety of oral alitretinoin in Korean CHE patients. METHODS A total of 27 patients with moderate to ...
متن کاملA case of sensitization to alitretinoin.
Alitretinoin is a unique retinoid authorised for the treatment of adults with severe chronic hand eczema (CHE) refractory to potent topical steroids. The most common adverse events (AEs) were typical class effects of oral retinoids including headache, flushing and skin disorders. To our knowledge, there are no cases of sensitization to alitretinoin reported in literature. We present a case of s...
متن کامل[Response to treatment with oral alitretinoin in patients with chronic hand eczema that is refractory to treatment with potent topical corticosteroids: experience in 15 patients].
BACKGROUND Alitretinoin (9-cis-retinoic acid) is an endogenous derivative of vitamin A and functions as an agonist of both families of nuclear receptors (retinoic acid receptor-α, -β, -γ; retinoid X receptor-α, -β, -γ). It has been investigated in the treatment of chronic hand eczema in many studies in recent years and the results have been promising. OBJECTIVES To evaluate the efficacy and s...
متن کامل